2021 FCS Playoff Bracketology It's much easier because of 64 teams vs 24 plus less travel (they're in pods of 4 so the winners of the 1st round don't travel to a new site for the next round) but in March Madness they do try to keep teams from the same conference away from each other as much as possible. I don't think they ever match up teams from the same conference in the 1st round and when possible, they try not to let two teams from the same conference meet until the regional finals.
That's because you have a lower percentage of teams from one conference. Google tells me the record for most teams from a conference in March Madness is 11, so less than 1/6 of the teams (this was a 68 team tourney). If the Big Sky gets 5, that's more than 1/5 (5/24). Second most in the NCAA tournament is 9, which is only 1/7th of the teams from one conference. So it's easier to spread things out. And the travel is potentially easier. Assuming you're not a 14-16 seed, you can get away with sending a 13 seed West Coast team out east (or vice versa) because if they win, they don't travel before the next game. If you send UCD to play, say, at Villanova in football and we win, then we have to fly back to Davis only to travel again a few days later.
I definitely agree though that it's fun to see teams that don't play each other face off. Always nice to see something new.